Nonsteroidal antiinflammatory drugs (NSAIDs)
Nonsteroidal antiinflammatory drugs (NSAIDs) are consumed by tens of millions worldwide. Although they relieve pain and inflammation, they also cause serious gastrointestinal and cardiovascular adverse effects and are thought to have caused hundreds of thousands of deaths. Despite enrolling more than 100,000 patients in randomized trials, we still do not know the NSAID of choice for patients with arthritis and heart disease or if NSAIDs differ in their clinical efficacy.
PENTACON investigators attempt to refine the use of NSAIDs so that they are used in patients individually most likely to benefit and least likely to suffer adverse effects.